Amitriptyline, administered orally, is currently one of the treatment options for the management of neuropathic pain and migraine.

​Amitriptyline is the best studied of the antidepressant agents in post-herpetic neuralgia and diabetic neuropathy. It is an effective treatment for these syndromes.

Amitriptyline is a first-line treatment option for chronic pain. It has demonstrated efficacy on varied patients with chronic pain unrelated to cancer.